KMID : 0861020100250040129
|
|
Korea Journal of Herbology 2010 Volume.25 No. 4 p.129 ~ p.135
|
|
The therapeutic effect of Achyranthis Radix on the collagen-induced arthritis in mice
|
|
Kim Chang-Soo
Park Yong-Ki
|
|
Abstract
|
|
|
Objectives: The present study was undertaken to determine whether the water extract of Achyranthis Radix, which is the roots of Achyranthes japonica (Achyranthis Radix, AR), is efficacious against collagen-induced arthritis (CIA) in DBA/1J mice.
Methods: Mice were immunized with bovine type ¥± collagen and orally treated with AR-W (50 and 100 §·/§¸/bw) from days 21 to 42 after immunization. Arthritis was evaluated by arthritic score, histological examination of knee joint and serological markers such as TNF-¥á, PGE2 and anti-type II collagen (C¥±)IgG.
Results: The results showed that comparing with untreated CIA mice, treated with AR-W significantly suppressed the clinical score and joint tissue pathological damages, reduced the serum levels of TNF-¥á, PGE2 and anti-C¥± IgG in CIA-mice. These results suggest that AR-W can effectively alleviate inflammatory response on CIA, and anti-inflammatoy of AR-W can be attributed, at least partially, to the inhibition of inflamamtory mediators, PGE2 and TNF-¥á, in CIA.
Conclusions: This study suggests that AR-W has a therapeutic potential in inflammatory joint diseases such as rheumatoid arthritis.
|
|
KEYWORD
|
|
Achyranthes japonica, Achyranthis Radix, anti-arthritis, collagen-induced arthriis, inflammation
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|
|